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National Research Foundation, Singapore (NRF)

HHP Challenges

Explore NRF’s HHP Challenges and contribute to mission-oriented research programmes tackling major health challenges in Singapore.

Last updated on 30 October 2026

NRF Human Health and Potential (HHP) is pleased to announce the Solicitation of Concept Papers for the Human Health and Potential (HHP) Challenges – Exercise One. The HHP Challenges is a new mission-oriented initiative under RIE2030 to address major health challenges of strategic importance to Singapore. These Challenges are designed to leverage Singapore's existing strengths in biomedical research and data, incorporating active programme management, clearly defined outcomes and defined timelines to deliver actionable impact over a 3–5-year horizon. 

This first solicitation exercise focuses on two challenge areas: Cardiovascular Health (focused on Heart Failure with Preserved Ejection Fraction, HFpEF) and Inflammation & Immunology (focused on Systemic Lupus Erythematosus, SLE). A cap of S$50 million per challenge area applies. Interested applicants are invited to submit their concept papers by 11 Dec 2026 (Fri), 2359 (SGT).  

Interested teams should contact HHP_Secretariat@nrf.gov.sg for more information on the submission, or further enquiries.